Tupelo High School's sixteen Advanced Placement (AP) courses have met the College Board's authorization.
This recognition identifies Tupelo's AP courses as meeting or exceeding the expectations colleges and universities have for AP subjects.
Twenty-five THS students were awarded Advanced Placement Scholar Distinction based on their AP scores from May 2007.
THS Advanced Placement Courses:
| AP English Language & Composition | AP United States History |
| AP English Literature & Composition | AP European History |
| AP Calculus AB | AP US Government & Politics |
| AP Statistics | AP Psychology |
| AP Biology | AP French |
| AP Chemistry | AP Spanish |
| AP Physics | AP Studio Art 2-D Design |
| AP World History | AP Art History |